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For infections for which prognosis is made by laboratory detection of particular antibodies (e.g., the hepatitis viruses and CMV), transplacental transfer of maternal antibodies that may persist within the infant for up to 18 months complicates the ability to make a diagnosis in younger infants. Strategy for analysis of congenital toxoplasmosis: analysis of strategies evaluating mothers and newborns and customary methods for postnatal detection of immunoglobulin G, M, and A antibodies. The usual serologic tests for syphilis in adults are based mostly on the measurement of IgG antibody. Data are limited relating to efficacy of PCV for children aged ≥5 years and for adults who're at high danger for pneumococcal infection. On the premise of restricted safety, immunogenicity, and efficacy information amongst HIV-contaminated kids, varicella and measles-mumps-rubella vaccines will be thought of for HIV-contaminated kids who usually are not severely immunosuppressed (i.e., these with age-particular CD4 cell percentages of ≥15%) (30--32). Practitioners ought to consider the potential risks and advantages of administering rotavirus vaccine to infants with identified or suspected altered immunocompetence; consultation with an immunologist or infectious diseases specialist is suggested. TMP--SMX, administered day by day for PCP prophylaxis, and azithromycin or atovaquone-azithromycin, administered for MAC prophylaxis, additionally might scale back the incidence of drug-sensitive serious bacterial infections in youngsters with recurrent serious bacterial infections. |
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