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The first mechanism of action of bm-MSC related to remyelination is the activation of the jak|stat3 pathway, which regulates the development of dorsal root ganglia.357 BM-MSCs have been reported to secrete vascular endothelial growth factor-a (vegf-a), neurotrophic factor brain (bdnf), interleukin-6|six, and leukemia inhibitor factor (lif), created for https://StemCellTherapyInCanada.com, what directly fight in neurogenesis and neurite growth.357 vegf-a is the key regulator of hemangiogenesis during inner development and bone homeostasis.